Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607651 | 0.98 | KMT2A (0.46) | KMT2AEPHX2RBP4HTTALDH1A1 | |
| SCHEMBL24664607 | 0.93 | KMT2A (0.46) | KMT2AEPHX2RBP4HTTALDH1A1 | |
| SCHEMBL8135298 | 0.82 | USP5 (0.48) | KMT2AALDH1A1 | |
| SCHEMBL14941550 | 0.82 | KMT2A (0.48) | KMT2AEPHX2HTTALDH1A1GAA | |
| SCHEMBL7804748 | 0.79 | KMT2A (0.50) | KMT2AEPHX2HTTALDH1A1HSD11B1 | |
| SCHEMBL14282244 | 0.79 | KMT2A (0.50) | KMT2AEPHX2HTTALDH1A1GAA | |
| SCHEMBL6444661 | 0.79 | HTT (0.63) | KMT2ARBP4HTTGAASMN1; SMN2 | |
| SCHEMBL30967266 | 0.79 | HTT (0.41) | KMT2AEPHX2HTTALDH1A1GAA | |
| SCHEMBL4412731 | 0.79 | KMT2A (0.52) | KMT2AEPHX2RBP4HTTALDH1A1 | |
| SCHEMBL14032638 | 0.76 | ALDH1A1 (0.49) | KMT2ARBP4ALDH1A1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |