Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 11/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2609308 | 0.77 | TLR9 (0.35) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL17586750 | 0.77 | TRPV3 (0.33) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL25928017 | 0.75 | TRPV3 (0.35) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL23514896 | 0.75 | KDM4E (0.35) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL14349193 | 0.74 | KDM4E (0.46) | — | |
| SCHEMBL19699659 | 0.72 | TRPV3 (0.37) | TRPV3IDO1TLR9TLR8TLR7 | |
| SCHEMBL13273393 | 0.72 | PDCD1LG2 (0.38) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL2609319 | 0.72 | CYP1A2 (0.33) | TRPV3TLR9TLR8TLR7 | |
| SCHEMBL23970899 | 0.72 | PARP1 (0.31) | — | |
| SCHEMBL27342258 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |