Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17342884 | 0.88 | KEAP1 (0.43) | JAK1ALDH1A1NAMPTKDM4EUSP2 | |
| SCHEMBL26027615 | 0.83 | NR1H2 (0.37) | GRM5HSD11B1JAK1ALDH1A1KDM4E | |
| SCHEMBL17888264 | 0.82 | KEAP1 (0.51) | HSD11B1ALDH1A1NAMPTTSHRKEAP1 | |
| SCHEMBL19226370 | 0.82 | KEAP1 (0.48) | HSD11B1ALDH1A1NAMPTTSHRKEAP1 | |
| SCHEMBL17888277 | 0.81 | KEAP1 (0.54) | HSD11B1ALDH1A1NAMPTTSHRKEAP1 | |
| SCHEMBL7920857 | 0.80 | NAMPT (0.47) | GRM5ALDH1A1NAMPTKDM4EKEAP1 | |
| SCHEMBL12286462 | 0.79 | MAPT (0.37) | JAK1ALDH1A1NAMPTKDM4EUSP2 | |
| SCHEMBL17888258 | 0.78 | NAMPT (0.51) | GRM5ALDH1A1NAMPTKDM4ETSHR | |
| SCHEMBL12286226 | 0.78 | CHRNB2 (0.46) | JAK1ALDH1A1NAMPTKDM4EUSP2 | |
| SCHEMBL17888278 | 0.78 | JAK1 (0.38) | GRM5JAK1ALDH1A1NAMPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |