Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | MGAM | O43451 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31516522 | 1.00 | PDGFRB (0.71) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL2397362 | 1.00 | PDGFRB (0.71) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL3164867 | 0.84 | PDGFRB (1.00) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL3164863 | 0.84 | PDGFRB (1.00) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL2399629 | 0.83 | KDM4E (0.66) | PDGFRBPDGFRARAB9AKMT2AKDM4E | |
| SCHEMBL2399632 | 0.83 | KDM4E (0.66) | PDGFRBPDGFRARAB9AKMT2AKDM4E | |
| SCHEMBL29978663 | 0.81 | PDGFRB (0.75) | PDGFRBPDGFRARAB9AKMT2AKDM4E | |
| SCHEMBL372256 | 0.80 | RAB9A (1.00) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL372255 | 0.80 | RAB9A (1.00) | PDGFRBPDGFRARAB9AMGAMKMT2A | |
| SCHEMBL17461333 | 0.80 | RAB9A (1.00) | PDGFRBPDGFRARAB9AMGAMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066627-B1 | NOVEL MINOR GROOVE BINDERS | UNIV STRATHCLYDE (GB) | 2013-10-23 | — | — | EP | disclosed |
| US-8012967-B2 | Minor groove binders | UNIVERSITY OF STRATHCLYDE (GB) | 2011-09-06 | — | — | US | disclosed |
| US-20100016311-A1 | NOVEL MINOR GROOVE BINDERS | UNIVERSITY OF STRATHCLYDE (GB) | 2010-01-21 | — | — | US | disclosed |
| EP-2066627-A1 | NOVEL MINOR GROOVE BINDERS | The University of Strathclyde (GB) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008038018-A1 | NOVEL MINOR GROOVE BINDERS | UNIVERSITY OF STRATHCLYDE (GB) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016311-A1 | NOVEL MINOR GROOVE BINDERS | TOP2B, DNA2, CTCF | PDGFRB 2009/4885PDGFRA 3203/4885RAB9A 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.