Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | PIM1 | P11309 | 4/20 | 0.50 |
| ▸ | CLK2 | P49760 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.50 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397446 | 1.00 | GPR119 (0.53) | GPR119DYRK1APIM1CLK2PIK3CD | |
| SCHEMBL2397451 | 1.00 | GPR119 (0.53) | GPR119DYRK1APIM1CLK2PIK3CD | |
| SCHEMBL1300086 | 0.85 | PIK3CG (0.53) | DYRK1APIM1CLK2PIK3CDCSNK2A2 | |
| SCHEMBL1300089 | 0.85 | PIK3CG (0.53) | DYRK1APIM1CLK2PIK3CDCSNK2A2 | |
| SCHEMBL1300088 | 0.85 | PIK3CG (0.53) | DYRK1APIM1CLK2PIK3CDCSNK2A2 | |
| SCHEMBL1299882 | 0.83 | IDE (0.47) | GPR119CLK1IDEMEN1KMT2A | |
| SCHEMBL12107156 | 0.83 | PIM1 (0.52) | DYRK1APIM1CLK2PIK3CDCSNK2A2 | |
| SCHEMBL12264963 | 0.81 | IDE (0.39) | GPR119DYRK1ACLK2PIK3CACLK1 | |
| SCHEMBL1497536 | 0.80 | DYRK1A (0.47) | GPR119DYRK1APIM1CLK2PIK3CD | |
| SCHEMBL1497533 | 0.80 | DYRK1A (0.47) | GPR119DYRK1APIM1CLK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475375-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | PIK3CA, PIK3CB, PIK3C2B | GPR119 997/4885DYRK1A 900/4885PIM1 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.