Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 4/20 | 0.37 |
| ▸ | KLK1 | P06870 | 4/20 | 0.37 |
| ▸ | KLK6 | Q92876 | 4/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995791 | 1.00 | LOXL2 (0.40) | LOXL2F9TPSAB1HDAC3HDAC6 | |
| SCHEMBL685444 | 0.88 | CA2 (0.39) | GRIA1MMEACEACE2MAPT | |
| SCHEMBL25454926 | 0.88 | CA2 (0.39) | GRIA1MMEACEACE2MAPT | |
| SCHEMBL20243835 | 0.87 | LOXL2 (0.37) | LOXL2F9TPSAB1HDAC3HDAC6 | |
| SCHEMBL12250719 | 0.86 | ESR1 (0.46) | GRIA1MMEACEACE2MAPT | |
| SCHEMBL12250692 | 0.86 | ATM (0.43) | MMEACEACE2MAPTCYP24A1 | |
| SCHEMBL13630710 | 0.86 | ESR1 (0.46) | GRIA1MMEACEACE2MAPT | |
| SCHEMBL10061085 | 0.86 | ATM (0.43) | MMEACEACE2MAPTCYP24A1 | |
| SCHEMBL26417010 | 0.86 | ATM (0.43) | MMEACEACE2MAPTCYP24A1 | |
| SCHEMBL12250708 | 0.86 | ESR1 (0.46) | GRIA1MMEACEACE2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827684-B2 | Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer | MERCK SHARP & DOHME LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-20210340207-A1 | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER | MERCK SHARP & DOHME CORP. (US) | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210340207-A1 | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER | IL2, IL2RA, IL6ST | LOXL2 1873/4885F9 2178/4885TPSAB1 2507/4885 |
| US-11827684-B2 | Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer | IL2, IL2RA, IL6ST | LOXL2 1873/4885F9 2178/4885TPSAB1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.