Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21842291 | 1.00 | SMN1; SMN2 (0.64) | SMN1; SMN2NAAAEPHX1HDAC3HDAC1 | |
| SCHEMBL23975362 | 0.98 | SMN1; SMN2 (0.66) | SMN1; SMN2NAAAEPHX1HDAC3HDAC1 | |
| SCHEMBL31501308 | 0.84 | NAAA (0.64) | NAAAEPHX1HDAC3HDAC1HDAC2 | |
| SCHEMBL31501326 | 0.84 | NAAA (0.64) | NAAAEPHX1HDAC3HDAC1HDAC2 | |
| SCHEMBL5655426 | 0.84 | NAAA (0.68) | SMN1; SMN2NAAAEPHX1EPHX2KEAP1 | |
| SCHEMBL7897834 | 0.84 | NAAA (0.68) | SMN1; SMN2NAAAEPHX1EPHX2KEAP1 | |
| SCHEMBL17172545 | 0.83 | NAAA (0.82) | SMN1; SMN2NAAAEPHX1HDAC8HDAC6 | |
| SCHEMBL38658755 | 0.83 | SMN1; SMN2 (0.91) | SMN1; SMN2EPHX1HDAC3HDAC1HDAC2 | |
| SCHEMBL31501321 | 0.83 | NAAA (0.61) | SMN1; SMN2NAAAEPHX1HDAC3HDAC1 | |
| SCHEMBL9829575 | 0.82 | NAAA (0.65) | SMN1; SMN2NAAAEPHX1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338825-A1 | DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338825-A1 | DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN | HAVCR2, CUL4A, PSMC3 | SMN1; SMN2 3617/4885NAAA 914/4885EPHX1 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.