Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975137 | 0.73 | CTSK (0.48) | SMN1; SMN2ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL23975141 | 0.72 | HDAC2 (0.42) | SMN1; SMN2RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL29088335 | 0.72 | CTSK (0.52) | SMN1; SMN2ALDH1A1GAARAB9AKMT2A | |
| SCHEMBL30465000 | 0.72 | CTSK (0.52) | SMN1; SMN2ALDH1A1GAARAB9AKMT2A | |
| SCHEMBL29088342 | 0.71 | CTSK (0.46) | SMN1; SMN2ALDH1A1RAB9AKMT2AHDAC3 | |
| SCHEMBL30465004 | 0.71 | CTSK (0.46) | SMN1; SMN2ALDH1A1RAB9AKMT2AHDAC3 | |
| SCHEMBL11910893 | 0.68 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL23884332 | 0.67 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL25189522 | 0.67 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL7294555 | 0.67 | ERCC1 (0.57) | ALDH1A1LMNAGAAKDM4EERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338825-A1 | DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338825-A1 | DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN | HAVCR2, CUL4A, PSMC3 | SMN1; SMN2 3617/4885ALDH1A1 1026/4885LMNA 3765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.