Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976125 | 0.92 | PARP1 (0.36) | HDAC1HDAC8HDAC6SPRPDE10A | |
| SCHEMBL23975862 | 0.91 | TUBB3 (0.38) | SYKHDAC1HDAC8HDAC6SPR | |
| SCHEMBL30484199 | 0.91 | TUBB3 (0.38) | SYKHDAC1HDAC8HDAC6SPR | |
| SCHEMBL23986789 | 0.89 | SYK (0.39) | SYKHDAC1HDAC8HDAC6SPR | |
| SCHEMBL30118625 | 0.88 | SYK (0.40) | SYKHDAC1HDAC8HDAC6PDE10A | |
| SCHEMBL23976064 | 0.88 | SYK (0.40) | SYKHDAC1HDAC8HDAC6PDE10A | |
| SCHEMBL23976413 | 0.87 | HDAC1 (0.33) | SYKHDAC1HDAC8HDAC6SPR | |
| SCHEMBL25918118 | 0.87 | HDAC1 (0.36) | SYKHDAC1HDAC8HDAC6SPR | |
| SCHEMBL23976137 | 0.87 | SYK (0.39) | SYKHDAC1HDAC8HDAC6PDE10A | |
| SCHEMBL23975777 | 0.87 | SYK (0.38) | SYKHDAC1HDAC8HDAC6SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |