Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975592 | 0.92 | SYK (0.38) | HDAC1HDAC8HDAC6PDE10ASPR | |
| SCHEMBL23976123 | 0.92 | KDM4E (0.38) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL30484199 | 0.90 | TUBB3 (0.38) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| SCHEMBL23975862 | 0.90 | TUBB3 (0.38) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| Formic Acid SCHEMBL30225275 | 0.89 | KDM4E (0.36) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL23987002 | 0.89 | KDM4E (0.36) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL23976372 | 0.88 | HDAC1 (0.38) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL23976947 | 0.88 | PDE10A (0.38) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL23976139 | 0.87 | HDAC1 (0.37) | PARP1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL23976413 | 0.86 | HDAC1 (0.33) | HDAC1HDAC8HDAC6PDE10ASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |