Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29415429 | 0.91 | ALDH1A1 (0.34) | LDHAP2RX7LMNAHDAC1HDAC6 | |
| SCHEMBL4276013 | 0.82 | NPC1 (0.39) | LMNAALDH1A1CYP3A4HSD17B10CTDSP1 | |
| SCHEMBL13139432 | 0.81 | NCF1 (0.38) | TSHRLMNAALDH1A1HSD17B10CTDSP1 | |
| SCHEMBL4272287 | 0.81 | CYP2D6 (0.44) | TSHRLMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL24702149 | 0.80 | HPGD (0.34) | TSHRLMNAHDAC1HDAC6HDAC5 | |
| SCHEMBL24702303 | 0.80 | NPY5R (0.36) | TSHRHDAC1HDAC6HDAC5 | |
| SCHEMBL34469739 | 0.79 | HDAC1 (0.34) | P2RX7HDAC1HDAC6HDAC5CTDSP1 | |
| SCHEMBL898231 | 0.79 | SOAT1 (0.44) | TSHRFAAHLMNACYP3A4 | |
| SCHEMBL3826445 | 0.78 | TAAR1 (0.42) | P2RX7HDAC1HDAC6HDAC5CYP1A2 | |
| SCHEMBL30226513 | 0.78 | ALDH1A1 (0.42) | P2RX7FAAHHDAC1HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |