Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975688 | 0.88 | METAP2 (0.46) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL23976150 | 0.87 | PDE10A (0.49) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL30118760 | 0.87 | PDE10A (0.49) | PDE10AMETAP2METAP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30225329 | 0.86 | PDE10A (0.48) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL23976572 | 0.86 | PDE10A (0.44) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL23976111 | 0.86 | PDE10A (0.46) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL10150242 | 0.85 | L3MBTL1 (0.50) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL30225178 | 0.85 | PDE10A (0.49) | PDE10AMETAP2METAP1MEN1KMT2A | |
| SCHEMBL23975705 | 0.85 | PDE10A (0.49) | PDE10AMETAP2METAP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30225193 | 0.84 | PDE10A (0.49) | PDE10AMETAP2METAP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |