⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896907 | 0.67 | — | — | |
| SCHEMBL8692973 | 0.67 | — | — | |
| SCHEMBL20859396 | 0.58 | — | — | |
| SCHEMBL21466394 | 0.58 | KEAP1 (0.42) | — | |
| SCHEMBL17772473 | 0.55 | — | — | |
| SCHEMBL2255302 | 0.53 | — | — | |
| SCHEMBL23976189 | 0.51 | — | — | |
| SCHEMBL12796574 | 0.50 | — | — | |
| SCHEMBL224442 | 0.50 | — | — | |
| SCHEMBL28635271 | 0.49 | TTR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015251-A1 | INHIBITORS OF HPK1 AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| CN-104447730-A | Oxazolidinone compounds and application thereof to drugs | GUANGDONG HEC PHARMACEUTICAL | 2015-03-25 | — | — | CN | disclosed |