Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.54 |
| ▸ | ECE1 | P42892 | 1/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.54 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | PLEC | Q15149 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298509 | 0.82 | KMT2A (0.66) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL26974362 | 0.82 | PGR (0.76) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL17832065 | 0.82 | TDP1 (0.62) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL17825550 | 0.82 | TDP1 (0.62) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL29712299 | 0.81 | MEN1 (0.78) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL17825554 | 0.81 | MEN1 (0.78) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL17825556 | 0.81 | MEN1 (0.78) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL17832067 | 0.81 | MEN1 (0.78) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL22179536 | 0.79 | PIK3CG (0.69) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL22179538 | 0.77 | KDM4E (0.69) | KMT2AMEN1POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225982-A1 | SOS1 ALLOSTERIC SITE TARGETING | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2021-11-11 | — | — | WO | disclosed |
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | UNIVERSITY OF CINCINNATI | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | SOS1, SOS2, SOST | KMT2A 3592/4885MEN1 554/4885POLB 4487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.