Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979061 | 0.89 | MAPT (0.36) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL30336865 | 0.76 | FGFR4 (0.36) | TDP1KDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL23978658 | 0.76 | FGFR4 (0.36) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL23978659 | 0.76 | FGFR4 (0.36) | TDP1KDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL30336944 | 0.76 | FGFR4 (0.36) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL23978706 | 0.75 | MAP3K5 (0.45) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL26496227 | 0.72 | KMT2A (0.38) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL15655786 | 0.66 | ALDH1A1 (0.45) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL23978660 | 0.66 | CYP1A2 (0.37) | FGFR4 | |
| SCHEMBL5999658 | 0.65 | KDM4E (0.41) | TDP1KDM4EKMT2ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |