Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979113 | 0.87 | EPHX2 (0.57) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL23979143 | 0.84 | EPHX2 (0.59) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL23978806 | 0.82 | EPHX2 (0.69) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL23979111 | 0.82 | LMNA (0.63) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL8108036 | 0.80 | EPHX2 (0.79) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL23978777 | 0.80 | ROCK2 (0.48) | MEN1KMT2A | |
| SCHEMBL13026611 | 0.78 | LMNA (0.65) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL7616443 | 0.75 | LMNA (0.65) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL3461067 | 0.75 | EPHX2 (0.66) | EPHX2LMNAHDAC4HDAC1HDAC7 | |
| SCHEMBL6361222 | 0.74 | TSHR (0.68) | LMNATSHRHPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |