Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.51 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979409 | 0.91 | CRBN (0.49) | DDB1CRBNIKZF3KDM4ENPC1 | |
| SCHEMBL23979457 | 0.86 | DDB1 (0.51) | DDB1CRBNIKZF3HCAR1ACVR1 | |
| SCHEMBL23979378 | 0.86 | DDB1 (0.51) | DDB1CRBNIKZF3ALDH1A1HCAR1 | |
| SCHEMBL23979379 | 0.86 | DDB1 (0.51) | DDB1CRBNIKZF3HCAR1CYP2D6 | |
| SCHEMBL3655337 | 0.84 | CRBN (0.57) | DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL27239098 | 0.80 | CRBN (0.60) | DDB1CRBNIKZF3ALDH1A1PARP1 | |
| SCHEMBL25654122 | 0.80 | CRBN (0.73) | DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL23979498 | 0.80 | CRBN (0.49) | DDB1CRBNIKZF3HCAR1PARP1 | |
| SCHEMBL3653400 | 0.79 | CRBN (0.59) | DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL19586745 | 0.79 | CRBN (0.76) | DDB1CRBNIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773080-B2 | Deuterium-enriched isoindolinonyl-azepanediones and related compounds and methods of treating medical disorders using same | SALARIUS PHARMACEUTICALS, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210340125-A1 | DEUTERIUM-ENRICHED ISOINDOLINONYL-AZEPANEDIONES AND RELATED COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | SALARIUS PHARMACEUTICALS, INC. | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773080-B2 | Deuterium-enriched isoindolinonyl-azepanediones and related compounds and methods of treating medical disorders using same | HPGDS, HPGD, AQP3 | DDB1 690/4885CRBN 1079/4885IKZF3 318/4885 |
| US-20210340125-A1 | DEUTERIUM-ENRICHED ISOINDOLINONYL-AZEPANEDIONES AND RELATED COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | HPGDS, HPGD, AQP3 | DDB1 690/4885CRBN 1079/4885IKZF3 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.