Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394160 | 0.94 | PGR (0.43) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2394873 | 0.89 | PGR (0.45) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2392224 | 0.87 | NR3C1 (0.45) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2397507 | 0.87 | KDM4E (0.47) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2391516 | 0.87 | PGR (0.49) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2390393 | 0.86 | NR3C1 (0.49) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2393531 | 0.86 | NR3C1 (0.46) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2395430 | 0.85 | PGR (0.46) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2393745 | 0.85 | PGR (0.47) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2395746 | 0.85 | NR3C1 (0.44) | PGRNR3C1ARESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420635-B2 | Method for preventing or treating a glucocorticoid receptor-related disease | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-04-16 | — | — | US | claimed |
| US-8017775-B2 | 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-13 | — | — | US | claimed |