Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30305409 | 1.00 | MAPT (0.43) | MAPTALDH1A1CHRM5MEN1KMT2A | |
| SCHEMBL30305511 | 0.91 | MAPT (0.42) | MAPTALDH1A1CHRM5MEN1KMT2A | |
| SCHEMBL30305504 | 0.90 | MAPT (0.42) | MAPTALDH1A1CHRM5MEN1KMT2A | |
| SCHEMBL23985885 | 0.90 | MAPT (0.42) | MAPTALDH1A1CHRM5MEN1KMT2A | |
| SCHEMBL25408630 | 0.86 | MAPT (0.41) | MAPTALDH1A1CHRM5MEN1KMT2A | |
| SCHEMBL30451216 | 0.85 | ALDH1A1 (0.41) | MAPTALDH1A1MEN1KMT2AHCRTR1 | |
| SCHEMBL25412808 | 0.84 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AHCRTR1 | |
| SCHEMBL26312997 | 0.84 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AHCRTR1 | |
| SCHEMBL25411495 | 0.83 | P2RX7 (0.38) | MAPTALDH1A1MEN1KMT2ARORC | |
| SCHEMBL30740452 | 0.83 | MAPT (0.39) | MAPTALDH1A1CHRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230353959-A1 | PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-11-02 | — | — | US | disclosed |
| US-20230353959-A1 | PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2023168378-A1 | PI3KA INHIBITORS | SYNNOVATION THERAPEUTICS, INC. (US) | 2023-09-07 | — | — | WO | disclosed |
| WO-2023168378-A1 | PI3KA INHIBITORS | SYNNOVATION THERAPEUTICS, INC. (US) | 2023-09-07 | — | — | WO | disclosed |
| CN-116261562-A | PI 3K-alpha inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-06-13 | — | — | CN | disclosed |
| WO-2021222556-A1 | PI3K-α INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |