Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965496 | 0.82 | CA1 (0.38) | CHRNB2CHRNA4CHRNB4NAMPTCA1 | |
| SCHEMBL23986453 | 0.81 | MEN1 (0.33) | CHRNB2CHRNA4ALDH1A1CHRNB4NAMPT | |
| SCHEMBL14593905 | 0.78 | POLB (0.47) | CHRNB2CHRNA4ALDH1A1CHRNB4NAMPT | |
| SCHEMBL4588092 | 0.77 | — | — | |
| SCHEMBL16440245 | 0.76 | CHRNB2 (0.33) | CHRNB2CHRNA4ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL23056505 | 0.75 | NAMPT (0.35) | CHRNB2CHRNA4ALDH1A1NAMPTCA1 | |
| SCHEMBL12384299 | 0.75 | ALDH1A1 (0.38) | CHRNB2CHRNA4ALDH1A1CHRNB4NAMPT | |
| SCHEMBL20561644 | 0.75 | ALDH1A1 (0.38) | CHRNB2CHRNA4ALDH1A1CHRNB4NAMPT | |
| SCHEMBL729759 | 0.75 | — | — | |
| SCHEMBL21121282 | 0.75 | EPHX2 (0.38) | ALDH1A1KDM4CKDM4APHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222114-A1 | BCL-2 PROTEIN INHIBITORS | RECURIUM IP HOLDINGS, LLC (US) | 2021-11-04 | — | — | WO | disclosed |