Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25590343 | 0.85 | LMNA (0.42) | LMNACNR1ADRA1ATDP1KDM4E | |
| SCHEMBL25589752 | 0.78 | MEN1 (0.35) | MEN1KMT2ACNR2 | |
| SCHEMBL8020618 | 0.75 | CNR2 (0.33) | CNR2 | |
| SCHEMBL24530159 | 0.75 | MEN1 (0.39) | MEN1KMT2ACNR2 | |
| SCHEMBL25590340 | 0.75 | MEN1 (0.39) | MEN1KMT2ACNR2 | |
| SCHEMBL23970178 | 0.73 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL4716380 | 0.73 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL23970350 | 0.73 | MEN1 (0.38) | MEN1KMT2ACNR2 | |
| SCHEMBL16203420 | 0.73 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL2348889 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021219828-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2021-11-04 | — | — | WO | disclosed |