Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396778 | 0.89 | PIK3CD (0.68) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2397288 | 0.81 | PI4KB (0.49) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2398248 | 0.76 | PIK3CD (0.40) | PIK3CDPI4KBPIK3CGPIK3CAPIK3CB | |
| SCHEMBL2400053 | 0.74 | PIK3CD (0.68) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2397182 | 0.73 | PIK3CD (0.49) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2393804 | 0.73 | PIK3CD (0.67) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2396076 | 0.72 | PIK3CD (0.72) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL48749 | 0.72 | PIK3CD (0.56) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL2397554 | 0.71 | PIK3CD (0.70) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA | |
| SCHEMBL21096715 | 0.71 | PIK3CD (0.75) | PIK3CDPI4KBPIK3CGPIK3C3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | MAP3K13, AKT3, MAP3K3 | PIK3CD 42/4885PI4KB 56/4885PIK3CG 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.