Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 20/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 5/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988809 | 0.91 | ACVR1 (0.39) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988740 | 0.87 | BMP4 (0.50) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988734 | 0.84 | ACVRL1 (0.48) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988892 | 0.80 | ACVR1 (0.33) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988756 | 0.79 | ACVR1 (0.33) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988675 | 0.74 | ACVR1 (0.67) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL23988822 | 0.69 | ACVR1 (0.72) | ACVR1BMPR1BBMPR1AACVR1BACVRL1 | |
| SCHEMBL24412000 | 0.67 | ACVR1 (0.83) | ACVR1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL23988749 | 0.66 | ACVR1 (0.76) | ACVR1BMPR1BBMPR1AACVR1BTGFBR1 | |
| SCHEMBL22074631 | 0.66 | ACVR1 (1.00) | ACVR1BMPR1BBMPR1AACVR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |