Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | BMP4 | P12644 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988925 | 0.89 | ACVR1 (0.46) | KDRKMT2AGAKFLT1FLT4 | |
| SCHEMBL23988901 | 0.83 | KDR (0.48) | KDRKMT2AGAKFLT1FLT4 | |
| SCHEMBL23988933 | 0.83 | KDR (0.45) | KDRKMT2AGAKFLT1FLT4 | |
| SCHEMBL19110507 | 0.83 | ACVR1 (0.53) | KDRKMT2AGAKFLT1FLT4 | |
| SCHEMBL23988879 | 0.77 | ACVR1 (0.54) | KDRKMT2AFLT1FLT4BMP4 | |
| SCHEMBL23988897 | 0.77 | KDR (0.51) | KDRFLT1FLT4BMP4ACVR1 | |
| SCHEMBL23988895 | 0.75 | ACVR1 (0.49) | KDRKMT2AGAKFLT1FLT4 | |
| SCHEMBL23988714 | 0.75 | FLT1 (0.68) | KDRFLT1FLT4BMP4ACVR1 | |
| SCHEMBL23988711 | 0.75 | ACVR1 (0.47) | KDRKMT2AGAKACVR1BMPR1A | |
| SCHEMBL17442182 | 0.75 | ACVR1 (0.52) | KDRKMT2AGAKFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |