Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 12/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558563 | 0.91 | PDPK1 (0.48) | PDPK1MTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL1559173 | 0.91 | MTOR (0.42) | PDPK1MTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL2396054 | 0.90 | MAP4K4 (0.46) | PDPK1MAP4K4MTORPIK3CAPIK3CD | |
| SCHEMBL1557499 | 0.90 | MKNK1 (0.44) | PDPK1MTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL1559013 | 0.90 | ALDH1A1 (0.41) | PDPK1TRPA1MTORPIK3CAPIK3CD | |
| SCHEMBL1558560 | 0.90 | PDPK1 (0.41) | PDPK1MTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL2394081 | 0.90 | MTOR (0.41) | PDPK1MTORPIK3CAPIK3CDPIK3CB | |
| SCHEMBL1558782 | 0.88 | MTOR (0.42) | PDPK1MAP4K4MTORPIK3CAPIK3CD | |
| SCHEMBL1559490 | 0.88 | TRPA1 (0.44) | PDPK1TRPA1MTORPIK3CAPIK3CD | |
| SCHEMBL1558604 | 0.88 | PDPK1 (0.41) | PDPK1MTORPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | PDPK1 29/4885MAP4K4 173/4885TRPA1 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.