Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25897312 | 0.78 | KDM1A (0.37) | KDM1ACHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL24867535 | 0.77 | KDM1A (0.40) | KDM1ACHRNB2CHRNA4MAOA | |
| SCHEMBL25005549 | 0.74 | GRIA4 (0.46) | KDM1AMAOAHRH3 | |
| SCHEMBL25005545 | 0.73 | HRH3 (0.43) | KDM1ACHRNA7CHRNB2CHRNA4MAOA | |
| SCHEMBL12030737 | 0.72 | DRD2 (0.39) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL2860558 | 0.72 | KDM4E (0.39) | KDM1AFASNELANE | |
| SCHEMBL25004715 | 0.71 | CHRNA7 (0.46) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL30181920 | 0.70 | KDM1A (0.33) | KDM1ACHRNA7MAOA | |
| SCHEMBL13596307 | 0.70 | CHRNB2 (0.65) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3555307 | 0.69 | CHEK1 (0.33) | KDM1AFASNELANEADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |