Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23993636 | 0.82 | SLC6A4 (0.41) | HDAC4PIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL25004761 | 0.81 | HDAC4 (0.39) | HDAC4PIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL726848 | 0.80 | HDAC4 (0.49) | HDAC4SMYD3RECQLSMN1; SMN2CTNNB1 | |
| SCHEMBL726857 | 0.80 | HDAC4 (0.46) | HDAC4PIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL725537 | 0.78 | HDAC4 (0.39) | HDAC4PIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL18828501 | 0.77 | HDAC4 (0.48) | HDAC4PIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL15798965 | 0.75 | ALDH1A1 (0.44) | HDAC4RECQLSMN1; SMN2CTNNB1WNT3A | |
| SCHEMBL15804941 | 0.75 | ALDH1A1 (0.44) | HDAC4RECQLSMN1; SMN2CTNNB1WNT3A | |
| SCHEMBL3369815 | 0.73 | MAPK9 (0.61) | NPC1SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL4781656 | 0.72 | HDAC4 (0.42) | HDAC4PIK3CAPIK3CGNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |