Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 6/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.39 |
| ▸ | NT5E | P21589 | 5/20 | 0.36 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994573 | 0.86 | NT5E (0.36) | NT5EPIM1PIM3PIM2RIPK1 | |
| SCHEMBL23993628 | 0.85 | NT5E (0.34) | NT5EPIM1PIM3PIM2RIPK1 | |
| SCHEMBL23994572 | 0.85 | NT5E (0.34) | NT5EPIM1PIM3PIM2RIPK1 | |
| SCHEMBL23994561 | 0.83 | RIPK1 (0.34) | NT5EPIM1PIM3PIM2RIPK1 | |
| SCHEMBL23995512 | 0.82 | NT5E (0.36) | NT5EPIM1PIM3PIM2RIPK1 | |
| SCHEMBL23994136 | 0.80 | NT5E (0.33) | NT5ERIPK1 | |
| SCHEMBL30181922 | 0.80 | NT5E (0.33) | NT5ERIPK1 | |
| SCHEMBL30181463 | 0.80 | NT5E (0.33) | NT5ERIPK1 | |
| SCHEMBL23995261 | 0.79 | KCNJ6 (0.36) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL25004500 | 0.78 | PDE10A (0.38) | KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |