Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 6/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25006021 | 0.87 | HTR2A (0.38) | KCNJ6KCNJ5KCNJ3HTR2AHTR2C | |
| SCHEMBL23995200 | 0.86 | HTR2C (0.34) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL23994564 | 0.85 | HTR2A (0.39) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL25589567 | 0.84 | HTR2A (0.32) | HTR2AHTR2CHTR2BKMO | |
| SCHEMBL30224760 | 0.80 | HTR2A (0.31) | HTR2AHTR2CHTR2B | |
| SCHEMBL25004502 | 0.80 | HTR2A (0.35) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL23995368 | 0.79 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL23994569 | 0.79 | KCNJ6 (0.34) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL25004360 | 0.78 | CYP17A1 (0.36) | KCNJ6KCNJ5KCNJ3PDE2A | |
| SCHEMBL23995447 | 0.77 | KCNJ6 (0.37) | KCNJ6KCNJ5KCNJ3PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |