Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 3/20 | 0.53 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.53 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.49 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 7/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24003745 | 0.92 | DNMT1 (0.49) | DNMT1DNMT3ADNMT3LMAPK8MAPK9 | |
| SCHEMBL24006278 | 0.85 | DNMT1 (0.56) | DNMT1DNMT3AEHMT1DNMT3LMAPK8 | |
| SCHEMBL24003987 | 0.85 | JAK2 (0.47) | MAPK8MAPK10BRAFSORT1HDAC3 | |
| SCHEMBL30287680 | 0.84 | NT5E (0.61) | DNMT1DNMT3AEHMT1DNMT3LBRAF | |
| SCHEMBL24006367 | 0.84 | NT5E (0.61) | DNMT1DNMT3AEHMT1DNMT3LBRAF | |
| SCHEMBL25461155 | 0.83 | DNMT1 (0.58) | DNMT1DNMT3AEHMT1DNMT3LBRAF | |
| SCHEMBL24003892 | 0.83 | BRAF (0.47) | MAPK8MAPK9MAPK10BRAFSORT1 | |
| SCHEMBL24010908 | 0.82 | BRAF (0.61) | BRAFNT5EMEN1KMT2A | |
| SCHEMBL30290852 | 0.82 | BRAF (0.61) | BRAFNT5EMEN1KMT2A | |
| SCHEMBL24010657 | 0.81 | BRAF (0.57) | DNMT1DNMT3AEHMT1DNMT3LBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |