Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317874 | 0.89 | DOT1L (0.41) | METAXLDOT1LPDGFRBPDGFRA | |
| SCHEMBL24003935 | 0.86 | WHR1 (0.44) | DOT1LNCF1ALDH1A1GAKMEN1 | |
| SCHEMBL26318323 | 0.85 | DOT1L (0.41) | METDOT1LPDGFRBPDGFRANCF1 | |
| SCHEMBL26311818 | 0.84 | DOT1L (0.41) | DOT1LPDGFRBPDGFRANCF1ALDH1A1 | |
| SCHEMBL26329742 | 0.83 | DOT1L (0.39) | METAXLDOT1LPDGFRBPDGFRA | |
| SCHEMBL26318330 | 0.83 | ALDH1A1 (0.40) | METAXLDOT1LNCF1ALDH1A1 | |
| SCHEMBL26311820 | 0.83 | GAK (0.40) | DOT1LPDGFRBPDGFRANCF1ALDH1A1 | |
| SCHEMBL25828249 | 0.83 | NCF1 (0.41) | DOT1LPDGFRBPDGFRANCF1ALDH1A1 | |
| SCHEMBL26317877 | 0.82 | DOT1L (0.38) | METAXLDOT1LPDGFRBPDGFRA | |
| SCHEMBL26329737 | 0.82 | DOT1L (0.39) | METDOT1LNCF1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| WO-2021226477-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | MET 1498/4885AXL 2809/4885DOT1L 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.