Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | TTR | P02766 | 3/20 | 0.73 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.73 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.73 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.73 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.73 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL29350388 | 1.00 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1244510 | 1.00 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1232980 | 0.98 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL6509233 | 0.98 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL7083032 | 0.98 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL21048102 | 0.98 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL40784 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL27229363 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL29385384 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1650617 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 49211 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075220-A | Contact lens for treating xerophthalmia and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075390-A | Preparation and application of novel cow uterus injectant | — | 2026-05-26 | — | — | CN | claimed |
| CN-121197040-B | In-situ carrier hydrogel based on nano bottle packaging technology and preparation method and application thereof | 上海大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122031445-A | External pharmaceutical composition containing loxoprofen | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| CN-122031449-A | External pharmaceutical composition containing loxoprofen and diclofenac | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| CN-122032567-A | Cobalt-doped cerium oxide spherical nanocluster catalyst and preparation method and application thereof | 华南师范大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031290-A | Percutaneous permeation promoting system and preparation method and application thereof | 北京工商大学 | 2026-05-15 | — | — | CN | claimed |
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| CN-122005686-A | External application medicine for subacute thyroiditis acute stage and preparation method thereof | 广东省中医院海南医院 | 2026-05-12 | — | — | CN | claimed |
| EP-0017169-B1 | IMPROVED ANTI-INFLAMMATORY COMBINATIONS HAVING REDUCED ULCEROGENICITY | MERCK & CO. INC. (US) | 1983-03-09 | — | — | EP | claimed |
| EP-0062429-A1 | Optical coupling devices for optical fibres | PLESSEY OVERSEAS LIMITED (GB) | 1982-10-13 | — | — | EP | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | claimed |
| US-4234601-A | 2-(DICHLOROPHENYLAMINO)-BENZENEACETIC ACID | MCNEILAB, INC. (US) | 1980-11-18 | — | — | US | claimed |
| EP-0017169-A1 | Improved anti-inflammatory combinations having reduced ulcerogenicity | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | claimed |
| EP-0012621-A1 | Analgesic composition comprising acetaminophen as a potentiating agent | McNeilab, Inc. (US) | 1980-06-25 | — | — | EP | claimed |
| WO-1980000661-A1 | PHARMACEUTICAL PREPARATIONS | CROFT J (NZ) | 1980-04-17 | — | — | WO | claimed |
| EP-0010061-A1 | Pharmaceutical preparations containing a mollusc extract | Mc Farlane, Stuart John (NZ) | 1980-04-16 | — | — | EP | claimed |
| EP-0004040-A1 | Pharmaceutical compositions having analgesic properties comprising a compound selected from D- and DL-phenylalanine, D- and DL-leucine and hydrocinnamic acid in the unit dose of at least 200mg | MERCK PATENT GmbH (DE) | 1979-09-19 | — | — | EP | claimed |