Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | GAA | P10253 | 1/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.94 |
| ▸ | TTR | P02766 | 3/20 | 0.73 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.73 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.73 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.73 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.73 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL29385384 | 1.00 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL8765115 | 1.00 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1232980 | 0.98 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL24009 | 0.97 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1650617 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL1244510 | 0.97 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL29350388 | 0.97 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL27229363 | 0.97 | PTGS2 (0.94) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL21048102 | 0.95 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA | |
| Diclofenac SCHEMBL6509233 | 0.95 | PTGS2 (0.97) | PTGS2PTGS1CYP2C9CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10362 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260097044-A1 | ION PAIR LIQUID CRYSTAL FORMULATIONS FOR LONG-ACTING INJECTABLES OF POORLY SOLUBLE DRUGS | FORDOZ PHARMA CORP. (US) | 2026-04-09 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260041660-A1 | Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms | CHANG RICHARD L (US) | 2026-02-12 | — | — | US | claimed |
| US-12539273-B2 | External nano liniment for gout and preparation method thereof | Zhang, Boke (US) | 2026-02-03 | — | — | US | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| WO-2025132620-A1 | STABLE SOFT CAPSULE PREPARATIONS WITH SOLID FILL FOR MOISTURE SENSITIVE ACTIVE INGREDIENTS | BAYER CONSUMER CARE AG (CH) | 2025-06-26 | — | — | WO | claimed |
| CN-119997773-A | Inverted perovskite solar cell based on recrystallization and preparation method thereof | 中国科学院宁波材料技术与工程研究所 | 2025-05-13 | — | — | CN | claimed |
| CN-1218692-A | Novel Anti-spasmodic composition and process for manufacture thereof | PANACEA BIOTEC LTD (IN) | 1999-06-09 | — | — | CN | claimed |
| US-5891913-A | ANTIINFLAMMATORY AGENT | NOVARTIS FINANCE CORPORATION (US) | 1999-04-06 | — | — | US | claimed |
| CN-1198323-A | Microstructure composition | CIBA GEIGY AG (CH) | 1998-11-11 | — | — | CN | claimed |
| WO-1998043630-A1 | MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 1998-10-08 | — | — | WO | claimed |
| EP-0868915-A1 | An anti-spasmodic and antiinflammatory composition containing a NSAID, pentifenone and fenpiverinium | PANACEA BIOTEC LIMITED (IN) | 1998-10-07 | — | — | EP | claimed |
| US-5674854-A | MIXING DICLOFENAC OR SALT AND BETA-CYCLODEXTRIN FORMING INCLUSION COMPLEX IN THE FORM OF SLURRY OR PASTE BY CONTINUOUS MIXING OF THE WATER, DRYING THE PRODUCT | FARMARC NEDERLAND BV (NL) | 1997-10-07 | — | — | US | claimed |
| EP-0785780-A1 | OPHTHALMIC AND AURAL COMPOSITIONS CONTAINING DICLOFENAC POTASSIUM | Novartis AG (CH) | 1997-07-30 | — | — | EP | claimed |
| WO-1996011003-A1 | OPHTHALMIC AND AURAL COMPOSITIONS CONTAINING DICLOFENAC POTASSIUM | NOVARTIS AG (CH) | 1996-04-18 | — | — | WO | claimed |
| CN-1107042-A | Inclusion complex | SOUTH AFRICAN DRUGGISTS LTD (ZA) | 1995-08-23 | — | — | CN | claimed |
| EP-0647451-A1 | Inclusion complex of beta-cyclodextrin with diclofenac | South African Druggist Limited (ZA) | 1995-04-12 | — | — | EP | claimed |