Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HBB | P68871 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103092 | 0.85 | POLB (0.66) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL8301655 | 0.82 | BACE1 (0.56) | NPSR1KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL5427929 | 0.82 | KDM4E (0.52) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL438970 | 0.82 | NR4A2 (0.60) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL8139912 | 0.82 | NPSR1 (0.54) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL5256820 | 0.82 | NPSR1 (0.54) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL859440 | 0.82 | MAPT (0.57) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL5433758 | 0.82 | KDM4E (0.56) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL5262076 | 0.81 | NPSR1 (0.52) | POLBNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL26400644 | 0.80 | NPSR1 (0.51) | POLBNPSR1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225969-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |