Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | GNG2 | P59768 | 1/20 | 0.47 |
| ▸ | GNB1 | P62873 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437286 | 0.86 | HSD17B10 (0.71) | NCF1ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL24009010 | 0.82 | POLB (0.58) | ALDH1A1HSD17B10NPSR1NQO2POLB | |
| SCHEMBL439632 | 0.81 | NR4A2 (0.54) | NR4A2NCF1ALDH1A1HSD17B10CASP1 | |
| SCHEMBL8139912 | 0.79 | NPSR1 (0.54) | ALDH1A1HSD17B10NPSR1NQO2POLB | |
| SCHEMBL859440 | 0.79 | MAPT (0.57) | NR4A2ALDH1A1HSD17B10NPSR1NQO2 | |
| SCHEMBL5256820 | 0.79 | NPSR1 (0.54) | ALDH1A1HSD17B10NPSR1NQO2POLB | |
| SCHEMBL23283481 | 0.79 | ACHE (0.46) | NCF1ALDH1A1HSD17B10NPSR1NQO2 | |
| SCHEMBL5262076 | 0.78 | NPSR1 (0.52) | ALDH1A1HSD17B10NPSR1NQO2POLB | |
| SCHEMBL26400644 | 0.77 | NPSR1 (0.51) | ALDH1A1HSD17B10NPSR1NQO2POLB | |
| SCHEMBL441893 | 0.76 | ACHE (0.44) | ALDH1A1HSD17B10KDM4EMPOACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024101337-A1 | QUINAZOLINE DERIVATIVES | 国立大学法人京都大学 | 2024-05-16 | — | — | WO | disclosed |
| CN-116323590-A | Substituted benzo or pyridopyrimidine amine inhibitor, preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115611865-A | Substituted benzo or pyrido pyrimidine amine inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2023-01-17 | — | — | CN | disclosed |
| WO-2022171018-A1 | SUBSTITUTED BENZOPYRIMIDINE OR PYRIDOPYRIMIDINE AMINE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-08-18 | — | — | WO | disclosed |
| CN-114907324-A | Substituted benzo or pyrido pyrimidine amine inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-08-16 | — | — | CN | disclosed |
| WO-2022083657-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-04-28 | — | — | WO | disclosed |
| CN-114380805-A | Substituted benzo or pyrido pyrimidine amine inhibitor and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| WO-2021081211-A1 | METTL3 MODULATORS | ACCENT THERAPEUTICS, INC. (US) | 2021-04-29 | — | — | WO | disclosed |
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |