Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798135 | 0.91 | KDM4E (0.49) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL9849499 | 0.86 | POLB (0.62) | KDM4EMAPTALDH1A1HPGDTSHR | |
| SCHEMBL24009010 | 0.82 | POLB (0.58) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8301655 | 0.79 | BACE1 (0.56) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5427929 | 0.79 | KDM4E (0.52) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL13802956 | 0.78 | KDM4E (0.54) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8139912 | 0.76 | NPSR1 (0.54) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL1634865 | 0.76 | MPO (0.60) | KDM4EMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5440887 | 0.75 | MPO (0.46) | KDM4EMAPTALDH1A1HPGDTSHR | |
| SCHEMBL4580511 | 0.75 | MDM4 (0.44) | KDM4EMAPTALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185079-A1 | Therapeutic agents I | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185079-A1 | Therapeutic agents I | HTT, GRIN2A, GRIN1 | KDM4E 2659/4885MAPT 35/4885ALDH1A1 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.