Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29256166 | 0.80 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL27887491 | 0.79 | CYP24A1 (0.45) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL28165269 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| Bromide SCHEMBL28351576 | 0.77 | CYP24A1 (0.44) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL1913708 | 0.76 | ALDH1A1 (0.44) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL30493226 | 0.76 | EGLN3 (0.47) | KDM4EALDH1A1CYP24A1HPGDALOX12 | |
| SCHEMBL5513660 | 0.76 | CYP17A1 (0.46) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL21624454 | 0.76 | CYP24A1 (0.40) | KDM4EALDH1A1CYP24A1MAPTPKM | |
| SCHEMBL15190326 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1MAPTPKMHPGD | |
| Bromide SCHEMBL28436281 | 0.75 | EGLN3 (0.46) | KDM4EALDH1A1CYP24A1HPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048890-B2 | Analgesics; neuropathic pain; headaches; muscle relaxants; incontence; tinnitus; diarrhea; antiarrhythmia agents; antiischemic agents; antiinflammatory agents; antiulcer agents; antidepressants; antiepileptic agents | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |
| US-20110224172-A1 | Substituted 1-Oxa-2,8-Diaza-Spiro [4,5] Dec-2-Ene Derivatives and Related Treatment Methods | GRUENENTHAL GMBH (DE) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224172-A1 | Substituted 1-Oxa-2,8-Diaza-Spiro [4,5] Dec-2-Ene Derivatives and Related Treatment Methods | SULT1E1, DECR1, CYP8B1 | KDM4E 356/4885ALDH1A1 156/4885CYP24A1 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.