Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 8/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290828 | 1.00 | JAK2 (0.55) | JAK2TYK2KCNK3KCNK9DNMT1 | |
| SCHEMBL24010215 | 0.87 | KCNK3 (0.58) | JAK2TYK2KCNK3KCNK9BRAF | |
| SCHEMBL1268265 | 0.86 | JAK2 (0.62) | JAK2TYK2KCNK3KCNK9MEN1 | |
| SCHEMBL24003832 | 0.86 | POLB (0.61) | JAK2TYK2KCNK3KCNK9DNMT1 | |
| SCHEMBL30232702 | 0.86 | POLB (0.61) | JAK2TYK2KCNK3KCNK9DNMT1 | |
| SCHEMBL24006101 | 0.86 | POLB (0.61) | JAK2TYK2KCNK3KCNK9DNMT1 | |
| SCHEMBL26321800 | 0.86 | ABL1 (0.59) | JAK2TYK2KCNK3KCNK9DNMT1 | |
| SCHEMBL24010242 | 0.85 | KCNK3 (0.75) | JAK2TYK2KCNK3KCNK9MEN1 | |
| SCHEMBL30290887 | 0.85 | MAPK8 (0.52) | JAK2TYK2BRAFPOLB | |
| SCHEMBL24010281 | 0.85 | MAPK8 (0.52) | JAK2TYK2BRAFPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| CN-115996721-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| WO-2021226458-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | JAK2 522/4885TYK2 2961/4885KCNK3 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.