Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 3/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 7/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24003832 | 0.91 | POLB (0.61) | KCNK3KCNK9ABL1BCRSRC | |
| SCHEMBL30232702 | 0.91 | POLB (0.61) | KCNK3KCNK9ABL1BCRSRC | |
| SCHEMBL24006101 | 0.91 | POLB (0.61) | KCNK3KCNK9ABL1BCRSRC | |
| SCHEMBL30290828 | 0.87 | JAK2 (0.55) | KCNK3KCNK9ABL1BCRSRC | |
| SCHEMBL24010533 | 0.87 | JAK2 (0.55) | KCNK3KCNK9ABL1BCRSRC | |
| SCHEMBL16964304 | 0.86 | KDM4E (0.61) | MAPTPOLBJAK2TYK2KDM4E | |
| SCHEMBL30290887 | 0.85 | MAPK8 (0.52) | MAPTPOLBJAK2TYK2BRAF | |
| SCHEMBL24010281 | 0.85 | MAPK8 (0.52) | MAPTPOLBJAK2TYK2BRAF | |
| SCHEMBL24010181 | 0.85 | KCNK3 (0.69) | KCNK3KCNK9MAPTPOLBSMN1; SMN2 | |
| SCHEMBL30290758 | 0.85 | KCNK3 (0.69) | KCNK3KCNK9MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| WO-2021226458-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | KCNK3 2240/4885KCNK9 4540/4885ABL1 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.