Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 12/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010281 | 1.00 | MAPK8 (0.52) | MAPK8MAPK10ACVRL1BRAFJAK2 | |
| SCHEMBL25821615 | 0.90 | ACVRL1 (0.54) | ACVRL1BRAFPOLBMAPT | |
| SCHEMBL30290823 | 0.88 | BRAF (0.49) | ACVRL1BRAFMAPTNT5E | |
| SCHEMBL24010134 | 0.88 | BRAF (0.49) | ACVRL1BRAFMAPTNT5E | |
| SCHEMBL24006426 | 0.88 | ACVRL1 (0.53) | MAPK8MAPK10ACVRL1BRAFJAK2 | |
| SCHEMBL24010533 | 0.85 | JAK2 (0.55) | BRAFJAK2TYK2POLB | |
| SCHEMBL30290828 | 0.85 | JAK2 (0.55) | BRAFJAK2TYK2POLB | |
| SCHEMBL24010215 | 0.85 | KCNK3 (0.58) | BRAFJAK2TYK2POLBMAPT | |
| SCHEMBL24003832 | 0.84 | POLB (0.61) | JAK2TYK2POLBMAPT | |
| SCHEMBL24006101 | 0.84 | POLB (0.61) | JAK2TYK2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115996721-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-4146212-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |