Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334924 | 0.84 | KDM4E (0.56) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL12355614 | 0.82 | GAA (0.49) | HTTALDH1A1TSHRMAPTHPGD | |
| SCHEMBL2894413 | 0.81 | HTT (0.46) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL3687994 | 0.79 | ALDH1A1 (0.43) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL5821566 | 0.78 | HTT (0.44) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL1883657 | 0.77 | KMT2A (0.55) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL279656 | 0.76 | ALDH1A1 (0.59) | HTTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL11739758 | 0.76 | MAPT (0.63) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL20418880 | 0.76 | KMT2A (0.44) | HTTALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL6458620 | 0.76 | ALDH1A1 (0.43) | HTTALDH1A1TSHRMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |