Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.58 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.56 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401524 | 1.00 | DPP4 (0.58) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL2403503 | 0.88 | PKM (0.58) | L3MBTL1MEN1KMT2APKM | |
| SCHEMBL2403509 | 0.88 | PKM (0.58) | L3MBTL1MEN1KMT2APKM | |
| SCHEMBL2401427 | 0.87 | DPP4 (0.56) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL2401429 | 0.87 | DPP4 (0.56) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL2401343 | 0.87 | EPHX2 (0.49) | DPP4DPP7KCNH2EPHX2HRH3 | |
| SCHEMBL2946427 | 0.87 | EPHX2 (0.49) | DPP4DPP7KCNH2EPHX2HRH3 | |
| SCHEMBL2401335 | 0.87 | EPHX2 (0.49) | DPP4DPP7KCNH2EPHX2HRH3 | |
| SCHEMBL2401696 | 0.86 | L3MBTL1 (0.50) | DRD2ADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL2401700 | 0.86 | L3MBTL1 (0.50) | DRD2ADRA1DADRA1AADRA1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017773-B2 | Cyclohexyl sulfonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-09-13 | — | — | US | disclosed |
| EP-1979322-B1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | disclosed |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | HRH3, HRH4, HRH1 | DPP4 1782/4885DPP7 2242/4885KCNH2 1064/4885 |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | HRH3, HRH4, HRH1 | DPP4 1782/4885DPP7 2242/4885KCNH2 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.