Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.35 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015971 | 1.00 | HCAR3 (0.42) | HCAR3L3MBTL1HPGDRORCTEAD1 | |
| SCHEMBL24015911 | 0.91 | RORC (0.36) | HCAR3HPGDRORCKDM4EHSD17B10 | |
| SCHEMBL24015912 | 0.91 | RORC (0.36) | HCAR3HPGDRORCKDM4EHSD17B10 | |
| SCHEMBL30375569 | 0.81 | TEAD1 (0.39) | HCAR3L3MBTL1HPGDRORCTEAD1 | |
| SCHEMBL25181308 | 0.81 | TEAD1 (0.39) | HCAR3L3MBTL1HPGDRORCTEAD1 | |
| SCHEMBL25181309 | 0.81 | TEAD1 (0.39) | HCAR3L3MBTL1HPGDRORCTEAD1 | |
| SCHEMBL24016097 | 0.80 | TEAD1 (0.43) | HCAR3L3MBTL1RORCTEAD1TEAD4 | |
| SCHEMBL24016092 | 0.80 | TEAD1 (0.43) | HCAR3L3MBTL1RORCTEAD1TEAD4 | |
| SCHEMBL24016196 | 0.78 | RORC (0.43) | RORC | |
| SCHEMBL24016038 | 0.76 | TEAD1 (0.55) | HCAR3L3MBTL1HPGDRORCTEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |