Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26464566 | 1.00 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1L3MBTL1 | |
| SCHEMBL25587522 | 0.86 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1L3MBTL1 | |
| SCHEMBL25587523 | 0.86 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1L3MBTL1 | |
| SCHEMBL25587521 | 0.86 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1L3MBTL1 | |
| SCHEMBL23666718 | 0.80 | IMPDH2 (0.48) | L3MBTL1SMN1; SMN2ALDH1A1TSHRCNR1 | |
| SCHEMBL24015529 | 0.75 | CYP3A4 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1SMN1; SMN2 | |
| SCHEMBL24015881 | 0.75 | CYP3A4 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1SMN1; SMN2 | |
| SCHEMBL15630941 | 0.73 | SMN1; SMN2 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1TSHRBLM | |
| SCHEMBL11989403 | 0.73 | SMN1; SMN2 (0.43) | L3MBTL1SMN1; SMN2ALDH1A1TSHRHDAC6 | |
| SCHEMBL24016012 | 0.72 | RAB9A (0.41) | SMN1; SMN2ALDH1A1TSHRCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |