Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25591483 | 0.85 | NPC1 (0.43) | POLBNPC1RAB9ATSHRHSD17B10 | |
| SCHEMBL31036989 | 0.85 | NPC1 (0.49) | POLBL3MBTL1NPC1ALOX12RAB9A | |
| SCHEMBL30202554 | 0.81 | CYP1A2 (0.57) | HSD17B10KCNA5CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL12993111 | 0.80 | MAPT (0.45) | TSHRHSD17B10MAPTCYP19A1SMN1; SMN2 | |
| SCHEMBL21460469 | 0.79 | ALDH1A1 (0.49) | RAB9ATSHRMAPTCDK2AKT1 | |
| SCHEMBL20318837 | 0.79 | ALDH1A1 (0.49) | RAB9ATSHRMAPTCDK2AKT1 | |
| SCHEMBL18228582 | 0.78 | ALDH1A1 (0.46) | POLBL3MBTL1TSHRCYP3A4ALDH1A1 | |
| SCHEMBL17065013 | 0.77 | CYP3A4 (0.44) | POLBL3MBTL1TSHRHSD17B10MAPT | |
| SCHEMBL14392243 | 0.76 | SLC6A4 (0.43) | TSHRHSD17B10MAPTCYP3A4CYP1A2 | |
| SCHEMBL19322924 | 0.76 | POLB (0.60) | POLBKCNA5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |