Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.60 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.60 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.60 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 9/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25042808 | 0.87 | USP2 (0.45) | TEAD1TEAD4TEAD2TEAD3GRM4 | |
| SCHEMBL24016573 | 0.85 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3BRAF | |
| SCHEMBL24016281 | 0.84 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3BRAF | |
| SCHEMBL30055916 | 0.83 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015646 | 0.83 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015693 | 0.82 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015783 | 0.81 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL24015665 | 0.81 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3TRPV1 | |
| SCHEMBL24016542 | 0.81 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3TRPV1 | |
| SCHEMBL24016138 | 0.81 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |