Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.61 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.61 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.61 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016137 | 0.84 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3BRAF | |
| SCHEMBL24016573 | 0.83 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3BRAF | |
| SCHEMBL24015693 | 0.81 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24016185 | 0.81 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3MEN1 | |
| SCHEMBL24015646 | 0.80 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015665 | 0.80 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3MEN1 | |
| SCHEMBL30055916 | 0.80 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24016542 | 0.80 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3MEN1 | |
| SCHEMBL24015783 | 0.80 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3EGFR | |
| SCHEMBL24016138 | 0.79 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |