Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015878 | 0.93 | HCAR3 (0.39) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016540 | 0.93 | HCAR3 (0.39) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24015879 | 0.93 | HCAR3 (0.39) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016537 | 0.91 | L3MBTL1 (0.51) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016110 | 0.90 | L3MBTL1 (0.53) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016562 | 0.88 | L3MBTL1 (0.39) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016515 | 0.88 | L3MBTL1 (0.39) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016092 | 0.87 | TEAD1 (0.43) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24016097 | 0.87 | TEAD1 (0.43) | L3MBTL1HCAR3TEAD1TEAD4TEAD2 | |
| SCHEMBL24015883 | 0.83 | TEAD1 (0.42) | L3MBTL1TEAD1TEAD4TEAD2TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |