Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.72 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.72 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.72 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | GCGR | P47871 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25597059 | 0.93 | TEAD1 (0.67) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24015683 | 0.93 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL30375620 | 0.93 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016129 | 0.92 | TEAD1 (0.74) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL25193481 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL30376337 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24016194 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL24015676 | 0.91 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL30375250 | 0.91 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 | |
| SCHEMBL25205098 | 0.91 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |