Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.72 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.72 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.72 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.72 |
| ▸ | METAP2 | P50579 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015683 | 1.00 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL25205098 | 0.94 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL30375250 | 0.94 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL24016563 | 0.93 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3CYP1A2 | |
| SCHEMBL24016194 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL30376337 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL25193481 | 0.92 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL24015676 | 0.91 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3CYP1A2 | |
| SCHEMBL25192817 | 0.90 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3METAP2 | |
| SCHEMBL30376313 | 0.90 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032625-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | Merck Patent KGaA (DE) | 2025-01-30 | — | — | US | disclosed |
| EP-4426700-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | Merck Patent GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250032625-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | TEAD1, UBQLN1, TTI1 | TEAD1 1/4885TEAD4 9/4885TEAD2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.